Cardio-oncologists should incorporate vascular prevention in their care, especially for those without protective hormones.
Women who undergo medical treatment for breast cancer are at greater risk for suffering from later vascular damage if they’ve already reached menopause, according to new data.
Among the female patients who received neoadjuvant chemotherapy using the TAC protocol, researchers found evidence of endothelial dysfunction in surgically removed mammary artery tissue of women who were postmenopausal but not those who were premenopausal. This illustrates the protective effect of estrogens against oxidative stress and in the inhibition of endothelial nitric oxide synthase (eNOS), they say.
Breast cancer therapies, including radiation and chemotherapy, are known to increase later cardiovascular…