Singapore ranks among the countries with the longest life expectancy in the world. Even so, many people spend close to their final ten years coping with poor health. Researchers at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) are working to change that reality by studying whether the biological process of aging itself can be altered to prevent age-related conditions, including Alzheimer’s disease.
In a study published in Aging Cell, scientists led by Professor Brian K Kennedy from the Department of Biochemistry and Chair of the Healthy Longevity Translational Research Programme (TRP), NUS Medicine, identified a promising role for calcium alpha-ketoglutarate (CaAKG). This naturally occurring and widely studied metabolite, known for its links to healthy aging, was found to restore…