Centrifuge technique creates functional bioengineered lymph nodes

Using a straightforward cell stacking method, researchers have regenerated functional lymph nodes, offering a potential long-lasting therapy for secondary lymphedema and creating new opportunities for immunology and oncology drug discovery.


The global rise of cancer has led to a growing number of surgical procedures involving the removal of lymph nodes. While these operations are essential for cancer staging and limiting the spread of disease, they can leave patients with serious long-term complications. One of the most debilitating is secondary lymphedema, a condition caused by the permanent loss of lymph nodes, which do not regenerate naturally once removed.

Secondary lymphedema’s symptoms include chronic swelling, pain and reduced mobility in affected limbs or body regions. These symptoms can…

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