ADVANCED maternal age was associated with a lower risk of several allergic diseases in early childhood, according to a large nationwide prospective birth cohort study conducted in Japan.
Study Rationale and Design
Advanced maternal age has been linked to genetic and epigenetic changes, but its relationship with allergic diseases in children has remained uncertain. To address this gap, researchers analysed data from the Japan Environment and Children’s Study, a nationwide population based prospective birth cohort. The study included 34,942 singleton mother child pairs enrolled between January 2011 and March 2014 across 15 regional centres, with follow-up assessments at child ages one, two, and four years. Parental age at childbirth was examined in relation to physician diagnosed allergic outcomes reported by…