DENGUE infection raised two-year hospitalization risk and added measurable disability burden in Singapore’s linked national cohort.
Dengue Infection and Two-Year Sequelae Risk
A large retrospective cohort study used Singapore’s linked national dengue surveillance and health care claims data to estimate postacute outcomes over the two years following dengue infection. Adults with dengue first notified between January 1, 2013, and June 30, 2022 were included, with exclusions for early death, reinfection, and certain SARS-CoV-2 timing windows. Each case was compared with matched controls with no recorded dengue, and analyses used overlap weighting to balance baseline characteristics.
Across 68,145 dengue infected adults and 2,886,119 controls, dengue infection was associated with higher risk of all cause…