CHILDREN with cystic fibrosis showed lower short chain fatty acids, associated with dietary patterns and inflammation.
Short Chain Fatty Acids in Cystic Fibrosis
Early life changes in fecal short chain fatty acid concentrations may help explain why many children with cystic fibrosis experience persistent gastrointestinal symptoms and inflammation. In a prospective longitudinal observational study, investigators compared 64 children with cystic fibrosis with 64 age matched healthy controls. Participants completed a validated food frequency questionnaire and provided stool samples for targeted liquid chromatography mass spectrometry short chain fatty acid profiling, fecal calprotectin testing, and 16S rRNA sequencing of the gut microbiota.
The analysis identified marked depletion of valerate and isobutyrate in…