High-throughput T-cell receptor sequencing reveals shared immune signatures in celiac disease, opening the door to earlier, less invasive diagnosis and disease monitoring.
Celiac disease (CD) is a chronic autoimmune disorder in which ingestion of gluten triggers an immune attack on the small intestine in genetically predisposed individuals. Affecting roughly one percent of the global population, its classic form is characterized by damage to the small bowel mucosa, leading to malabsorption and a range of gastrointestinal symptoms, including chronic diarrhea, abdominal pain and distension, weight loss, and, in children, poor growth.
However, recent screening studies in children and adolescents suggest that the prevalence of CD may be much higher, reaching approximately three percent in certain populations. This suggests…