Interactions between the human microbiome and cancer biology are increasingly recognized as clinically relevant drivers of tumor behavior. Although bacterial and viral contributions to oncogenesis have been widely studied, fungal influences remain comparatively underexplored. Emerging preclinical evidence now suggests that fungal organisms residing within the human microbiota, termed the mycobiome, may actively shape melanoma progression, raising new questions about the tumor microenvironment and potential therapeutic targets.
Direct interactions between melanoma cells and the commensal fungus Candida albicans may promote tumor aggressiveness through metabolic and angiogenic reprogramming, according to findings published in Scientific Reports.
Investigators examined whether C albicans, a common component of the human…