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Interest in mRNA vaccines has surged in recent years, largely due to the success and widespread attention of COVID-19 vaccines using this technology. The speed of their development, the robust protection they provide, and their favorable safety profiles have demonstrated the wide-ranging potential of mRNA technology. However, the potential of mRNA goes far beyond infectious diseases. In oncology, mRNA vaccines are being explored as a personalized therapeutic strategy that trains a patient’s immune system to recognize tumor-specific mutations. This targeted strategy harnesses the body’s natural defenses to fight cancer cells while sparing healthy tissue, offering a promising complement to existing therapies. As oncology nurses, understanding the principles behind mRNA vaccines and…