Early Alzheimer’s Signals Found With Spatial Proteomics

The brain undergoes significant changes with age, but at what point does normal aging turn into a disease?

 

Researchers at Boston University (BU) School of Medicine developed a high-resolution mapping technique to identify these early disease-linked changes. Their study uncovered specific protein and sugar signatures that differentiate healthy aging from Alzheimer’s disease (AD) and Lewy body pathology.

The molecular link between aging and Alzheimer’s

Identifying brain disorders such as AD or Lewy body disease (LBD) usually happens too late; by the time a doctor confirms a diagnosis, the brain has already suffered irreversible damage. This diagnostic delay is a big hurdle in modern neurology.

 

Aging naturally changes how our brain functions, often leading to a buildup of misfolded proteins….

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