The study, published in PNAS, shows that while individual cancer cells can probe about 10 microns ahead by pulling on collagen fibers, clusters of normal epithelial cells can extend this sensing range up to 100 microns when acting collectively.
Researchers describe this phenomenon as “depth mechano-sensing.” “Depth mechano-sensing describes the process that allows cells to detect features beyond the surface they are attached to,” said Amit Pathak, professor at the McKelvey School of Engineering.
The mechanism relies on cells deforming collagen fibers in the extracellular matrix. By tugging and reshaping these fibers, cells can “feel” nearby structures such as stiff tumors, soft tissues, or even bone, helping them determine where to move.
The study found that collective cell behavior…