Electroacupuncture relieves pain-induced anxiety through prefrontal neural circuits

Neuropathic pain, caused by injury or disease of the somatosensory nervous system, is a major clinical challenge and often evolves into a chronic condition. Importantly, up to 80% of patients with long-term pain also experience anxiety or depression. This creates a vicious cycle that not only worsens prognosis and quality of life but also poses significant challenges for treating both the pain and the accompanying emotional disorders. Current treatments mainly focus on pain intensity, while emotional symptoms often remain inadequately addressed.

Acupuncture, an ancient Chinese practice, is now widely recognized and integrated into global pain management. It offers a drug-free option for conditions such as chronic back pain, migraines, and arthritis. High-quality clinical trials have further confirmed its…

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