NIH funds AI project to advance Alzheimer’s research and treatment

The National Institutes of Health has renewed support for Artificial Intelligence for Alzheimer’s Disease, or AI4AD. The new $12.6 million award to advance the project’s next phase, AI4AD2, brings its total investment in AI4AD to $30.7 million. Led by Paul M. Thompson, PhD, associate director of the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) … Read more

Digital twin hearts improve outcomes in arrhythmia ablation procedures

Working with “digital twins” of patients’ hearts, doctors improved cardiac ablation outcomes for patients with life-threatening arrythmias. In the first clinical trials for cardiac digital twins technology, researchers at Johns Hopkins University created digital replicas of patients’ hearts, then tested procedures on those twins before performing them on the real thing. Working with digital twins … Read more

Small molecule may block protein buildup in neurodegenerative diseases

A team of researchers from NYU Abu Dhabi and the University of Denver have identified a promising small molecule that could help slow or halt the progression of serious brain diseases such as Parkinson’s disease, offering new hope for treatments that go beyond managing symptoms. These diseases, which also include Lewy body dementia and multiple … Read more

Sleep duration and genetics interact to affect functional health

Lifestyle-behavioral factors and socioeconomic status play an important role in shaping healthy aging, but their effects may differ depending on your DNA, according to a new international study led by Adelaide University researchers. The study is the first of its kind to show that diet quality, physical activity, sleep, smoking, education, employment and social engagement … Read more

New therapy reprograms immune cells to reduce asthma inflammation

A collaborative effort between researchers at the Henan Academy of Innovations in Medical Science, Zhengzhou University, and Shenzhen University School of Medicine has provided the first proof-of-principle study demonstrating that targeting a receptor on the surface of anti-inflammatory regulatory T cells (Tregs) can restore their function and alleviate asthma in mice. The study, published March … Read more

Lipid nanoparticles help CAR T cells melt pancreatic cancer barriers

Often diagnosed when surgery is no longer an option, pancreatic cancer is one of the most difficult cancers to treat and has one of the lowest rates of survival among major malignancies. Like many solid tumors, the most common type of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), is shielded by the desmoplastic matrix-a dense barrier … Read more

Lifestyle care in primary clinics allows for safe diabetes deprescribing

A new research study provides real-world evidence that deprescribing glucose‑lowering medications is both feasible and safe when patients with type 2 diabetes receive lifestyle‑informed care in primary care settings. The retrospective chart review, published in the Journal of Clinical Medicine, examined electronic health records from 650 adults with type 2 diabetes receiving care at two … Read more

ACLM launches project remission for Type 2 diabetes

The American College of Lifestyle Medicine (ACLM) announces the launch of Project Remission: A Lifestyle Medicine Approach to Type 2 Diabetes, a national digital film series developed in partnership with Content With Purpose (CWP). Premiering during a live webinar featuring experts in the field at noon CT today, with the full series also launching digitally, the … Read more

Whole genome sequencing improves diagnosis of rare diseases

A collaboration between Karolinska Institutet, Karolinska University Hospital, and SciLifeLab has integrated whole genome sequencing into routine diagnostic investigations for rare diseases at Karolinska University Hospital. To date, more than 15,000 patients have had their entire genome sequenced, with 23 per cent receiving a genetic diagnosis, according to a study published in Genome Medicine. The … Read more