chimeric immunoreceptors

Muscle Mass May Presage CAR T Outcomes

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TOPLINE: Sarcopenia, a hallmark of cancer cachexia, is associated with poor outcomes in chimeric antigen receptor (CAR) T-cell therapy, which can exacerbate muscle loss through inflammatory responses. The relationship between CAR T-cell therapy, sarcopenia, and metabolism requires further investigation to improve patient outcomes. METHODOLOGY: Researchers measured skeletal muscle index from clinical images in 83 patients … Read more

Neuroblastoma Superstars: Cases of Exceptional Survival

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In 2017, Stephanie Uy learned that her 22-month-old daughter, Aspen, had stage IV high-risk neuroblastoma. The cancer, which develops from the sympathetic nervous system, is the most common type of solid tumor in children outside of the brain. Patients with high-risk neuroblastoma tend to be older than 18 months at diagnosis, have amplification of the … Read more