Long-Read Nanopore Sequencing Improves Rare Disease Diagnosis

Whole genome sequencing (WGS) is not necessarily a solution for someone with a rare, monogenic disease. Indeed, more than half of families with suspected rare monogenic diseases do not have an answer after WGS when short-read sequencing is performed. Now, a group of researchers present data that suggests that long-read sequencing may be the better … Read more

Genetic Variants in OUD Risk Algorithm Do Not Meet Standards in Identifying Risk

Christal N. Davis, PhD Credit: ResearchGate A recent study suggested that the genetic variants in the opioid use disorder (OUD) risk algorithm do not meet reasonable standards in identifying OUD risk.1 “We found no evidence to support the clinical utility of the 15 [single nucleotide variants] purported to predict OUD risk,” wrote investigators, led by … Read more