Host-pathogen interaction

Mitigating host microRNA interference to enhance mRNA vaccine efficacy in public health interventions | Infectious Diseases of Poverty

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Translation of mRNA vaccines in APCs is an initial step to elicit immunity An mRNA vaccine delivers a genetic “instruction manual” (mRNA) that teaches cells to translate a harmless piece of the target pathogen (i.e., antigen). Specialized cells called APCs—the body’s “intelligence agents”—swallow the vaccine particles. These APCs perform three critical tasks: (1) capture: swallow … Read more

Reassessing Schistosoma worms: the overlooked role in host pathology and disease elimination | Infectious Diseases of Poverty

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Schistosomiasis, a neglected tropical disease (NTD), remains a significant public health challenge, more than 800 million people worldwide live in areas endemic for schistosomiasis, particularly in low- and middle-income countries [1]. In certain regions, such as China, decades of integrated control measures have successfully reduced the prevalence of the disease to historically low levels [2]. … Read more