Research reveals how the dietary flavonoid promotes regulatory T cell development and suppresses inflammation through key immune pathways.
Study: Kaempferol Exerts Anti-Inflammatory Effects by Accelerating Treg Development via Aryl Hydrocarbon Receptor-Mediated and PU.1/IRF4-Dependent Transactivation of the Aldh1a2/Raldh2 Gene in Dendritic Cells. Image Credit: Danijela Maksimovic/Shutterstock.com
In a recent article published in the Allergy, a group of researchers studied how kaempferol, a dietary flavonoid, promotes regulatory T cell (Treg) development by activating the Aldh1a2/Raldh2 gene in dendritic cells through the aryl hydrocarbon receptor (AhR) and PU.1/IRF4 pathways.
Background
Raldh2, encoded by the Aldh1a2 gene, is expressed in intestinal dendritic cells (DCs) and plays a critical role…