Ligand

APOE4 alters brain immunity and cognition differently in females and males

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A new study shows that APOE4 reshapes brain-linked immune and lymphatic pathways in strikingly different ways in females and males, with opposite cognitive effects when innate immunity is suppressed. Study: Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition. Image Credit: ahmetmapush / Shutterstock In a recent study published in the journal Neuron, … Read more

Optibrium introduces graphical interface for QuanSA to enhance ligand-based affinity predictions

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Optibrium, a leading developer of software and AI solutions for molecular design, today announced a new QuanSA™ plugin for PyMOL, providing an intuitive Graphical User Interface (GUI) for its ligand-based binding affinity prediction method, part of the Company’s BioPharmics 3D molecular modelling platform. The new interface facilitates chemists’ access to accurate affinity predictions that guide … Read more

Investigating microglia’s role in Alzheimer’s pathology

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Announcing a new article publication for BIO Integration journal. Alzheimer’s disease (AD) is a neurodegenerative disorder and the leading cause of dementia worldwide. Microglia, as central nervous system (CNS) resident macrophages, are key to AD pathology. Indeed, microglia aggregation around amyloid-β (Aβ) deposits is an AD hallmark. Triggering receptor expressed on myeloid cells 2 (TREM2) … Read more

Thermodynamic insights into histamine H1 receptor ligand binding

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G-protein-coupled receptors (GPCRs) are one of the largest families of cell surface proteins in the human body that recognize hormones, neurotransmitters, and drugs. These receptors regulate a wide range of physiological processes and are the targets of more than 30% of currently marketed drugs. The histamine H1 receptor (H1R) is one such GPCR subtype that … Read more

RNA micelles enable targeted chemotherapy without immune toxicity

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A new study in mice hints at the potential to use tiny particles made with RNA molecules to deliver chemotherapy drugs and other therapies directly to tumors, killing cancer cells without generating an immune response or toxicity-related side effects. Researchers constructed tiny molecular clusters called RNA micelles, loaded them with potent chemo drugs and an … Read more

Immune microRNAs drive new frontiers in cardiovascular disease research

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  Cardiovascular diseases (CVDs) continue to dominate global mortality statistics, with immune dysregulation emerging as a central feature in their pathogenesis. This review by Gareev et al. focuses on immune-derived microRNAs (immuno-miRs) as pivotal modulators of immune responses in cardiovascular settings, highlighting their roles in pathophysiology, diagnostic potential, and therapeutic promise. Introduction … Read more

New insights into therapy resistance in breast cancer

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A new review was published in Oncotarget, Volume 16, on March 13, 2025, titled “Signaling pathway dysregulation in breast cancer.” In this review article, Dinara Ryspayeva and colleagues from Brown University provide a detailed look at how breast cancer cells change the way they communicate and grow-helping tumors survive, spread, and resist treatment. The review … Read more

Understanding the mechanisms behind alcohol-associated liver disease

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A newly published review in eGastroenterology compiles recent research on alcohol-associated liver disease (ALD), offering an overview of its pathogenesis and efforts to better understand this condition. ALD, caused by excessive alcohol consumption, remains a significant contributor to liver-related mortality worldwide. Effective treatments are still limited, underscoring the need for a deeper understanding of its … Read more

Kaempferol boosts immune tolerance and fights allergies

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Research reveals how the dietary flavonoid promotes regulatory T cell development and suppresses inflammation through key immune pathways. Study: Kaempferol Exerts Anti-Inflammatory Effects by Accelerating Treg Development via Aryl Hydrocarbon Receptor-Mediated and PU.1/IRF4-Dependent Transactivation of the Aldh1a2/Raldh2 Gene in Dendritic Cells. Image Credit: Danijela Maksimovic/Shutterstock.com In a recent article published in the Allergy, a group of researchers studied … Read more