Osteoporosis is a major health concern worldwide, particularly in aging populations. Despite pharmacological advancements, challenges like side effects, costs, and limited accessibility reduce adherence to treatments. Recently, the gut microbiome has gained attention for its potential role in bone metabolism. Yet, aging complicates its stability and influence, raising the need to explore alternative mechanisms behind bone loss. Given these challenges, researchers aimed to investigate non-microbial contributors to age-related bone deterioration.
A collaborative study led by Harvard Medical School, published (DOI: 10.1038/s41413-024-00366-0) in Bone Research on November 08, 2024, tackled this question. Using advanced genetic sequencing and metabolomic tools, scientists examined bone health in CB6F1 mice…