Researchers have demonstrated a new class of low-cost, scalable sensors that can be used to monitor electrical activity in human cerebral organoids. Because electrical signals are key to understanding brain function, this advance facilitates research into both neurodevelopment and genetic disorders such as Angelman syndrome. Human cerebral organoids are millimeter-sized tissues comprised of cell types … Read more
The National Institutes of Health has renewed support for Artificial Intelligence for Alzheimer’s Disease, or AI4AD. The new $12.6 million award to advance the project’s next phase, AI4AD2, brings its total investment in AI4AD to $30.7 million. Led by Paul M. Thompson, PhD, associate director of the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) … Read more
A new map of a brain circuit specific to chronic pain suggests a promising route to treatment for the roughly 60 million Americans living with persistent pain, according to a study published in Nature. The study showed that silencing the specific cells that drive this circuit eased chronic pain while preserving acute pain responses-in other words, the body’s … Read more
Cholera-causing bacteria are locked in an evolutionary arms race with a viral nemesis, according to a new genomic study. Experts at the Wellcome Sanger Institute, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh), the Post Graduate Institute of Medical Education & Research (PGIMER), and their collaborators, found that in the Ganges Delta, cholera bacteria rapidly … Read more
Hiroshima University researchers have developed a practical framework to identify candidate pathogenic variants hidden among the large number of variants of uncertain significance (VUS) detected in comprehensive genomic profiling (CGP) of cancers. This framework could improve the accuracy of precision oncology by more reliable prioritization of VUS. Comprehensive genomic profiling (CGP) enables comprehensive detection of … Read more
Lifestyle-behavioral factors and socioeconomic status play an important role in shaping healthy aging, but their effects… The post Sleep & Genetics: Impact on Health | [Your Brand] appeared first on Archynetys. Source link
A new global initiative launched today aims to close a critical gap in ALS/MND drug discovery – current cell models used for testing treatments do not currently reflect the diverse nature of the disease – that affects both researchers developing therapies and the people urgently waiting for them. The ALS Therapy Development Institute (ALS TDI), … Read more
Lifestyle-behavioral factors and socioeconomic status play an important role in shaping healthy aging, but their effects may differ depending on your DNA, according to a new international study led by Adelaide University researchers. The study is the first of its kind to show that diet quality, physical activity, sleep, smoking, education, employment and social engagement … Read more
Researchers combined genetic epidemiology, transcriptomics, molecular docking, and mouse experiments to show how a common endocrine-disrupting chemical may influence biological pathways tied to major depressive disorder. Study: Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation. Image Credit: monticello / Shutterstock A new study … Read more
Autism has a significant and enduring sex bias, with roughly four boys diagnosed for every girl. For many years, experts have believed this disparity arises primarily from diagnostic inequities because much of autism research – and the screening tools that grew out of it – has historically focused on boys, effectively setting a male standard … Read more