TOPLINE:
Compared with standard concurrent chemoradiation, neoadjuvant chemotherapy followed by transoral robotic surgery (NECTORS) and neck dissection led to superior distant metastasis-free and overall survival outcomes in patients with advanced human papillomavirus–related oropharyngeal squamous cell carcinoma (HPV-OPSCC).
METHODOLOGY:
- Distant metastasis is a leading cause of death in patients with HPV-OPSCC, and standard of care concurrent chemoradiation carries significant long-term toxicities and may not address occult micrometastasis. De-escalation strategies such as NECTORS offer a potential alternative by addressing micrometastasis while sparing patients from radiation-related side effects.
- To assess the potential survival benefits of NECTORS, researchers compared outcomes in patients with stage III and IVa…