Researchers at the University of Nottingham have developed a new genetic test that can diagnose brain tumours in as little as 2 hours The test, called ROBIN, uses PromethION nanopore sequencing to deliver rapid methylome classification. The researchers said results could be available intraoperatively, allowing clinicians to make faster, more informed decisions. The same assay … Read more
TOPLINE: In patients with metastatic breast cancer (BC), the prevalence of brain metastases increased with each treatment line, rising the most among patients with hormone receptor (HR)–negative, human epidermal growth factor receptor 2 (HER2)–positive disease and the least among those with HR-positive, HER2-negative disease. METHODOLOGY: Brain metastases indicate a poor prognosis in patients with metastatic … Read more
TOPLINE: In patients with ERBB2-positive metastatic breast cancer (ERBB2+ MBC) and brain metastasis, more than half of deaths were due to central nervous system (CNS)–related causes; however, patients with CNS-only metastasis have significantly longer overall survival than those with both CNS and extracranial metastasis. METHODOLOGY: About one third of patients with ERBB2+ MBC develop brain … Read more
New research, with the caveat of a relatively short follow-up, adds to encouraging data showing an overall low risk of the development of thyroid cancer associated with glucagon-like peptide 1 receptor agonist (GLP-1 RA) treatment. However, a notably increased rate of thyroid cancer detections limited only to the first year after drug initiation — but … Read more
In the largest study of its kind involving a diabetic population, the use of glucagon-like peptide 1 receptor agonist (GLP-1 RA) drugs shows no significantly increased risk for thyroid cancer, with the important caveat of the study’s relatively short follow-up period. “In this large multisite study utilizing data from 6 population-based databases, we found no … Read more
TOPLINE: Compared with standard concurrent chemoradiation, neoadjuvant chemotherapy followed by transoral robotic surgery (NECTORS) and neck dissection led to superior distant metastasis-free and overall survival outcomes in patients with advanced human papillomavirus–related oropharyngeal squamous cell carcinoma (HPV-OPSCC). METHODOLOGY: Distant metastasis is a leading cause of death in patients with HPV-OPSCC, and standard of care concurrent … Read more