Introduction
Sepsis is a life-threatening disease associated with an imbalance in the host’s response to infection. There are over 40 million new cases of sepsis worldwide annually, with approximately 10 million deaths, posing a serious threat to life and health.1 Septic shock is a form of sepsis characterized by inadequate circulation and cellular hypoxia, which is a form of sepsis.2 The mortality rate of patients with septic shock exceeds 40%, making it the leading cause of death beyond myocardial infarction.3 Therefore, biomarkers for early diagnosis and prognostic evaluation are of great significance in improving the clinical management of septic shock.
In recent years, serum biomarkers have received increasing attention for diagnosis, disease assessment, and prognosis prediction of sepsis. Serum biomarkers are…