The possibility of type 2 diabetes (T2D) remission has been widely debated in recent years, primarily due to studies investigating the effects of calorie restriction and weight loss on glycemic control. However, experts warn that achieving normal blood glucose and glycated hemoglobin levels does not necessarily mean disease reversal.
“At the time of diagnosis, approximately 50% of beta-cell function is already compromised. Many of these cells die through apoptosis and cannot be recovered,” said Luciano Giacaglia, MD, PhD, endocrinologist and coordinator of T2D and prediabetes at the Brazilian Diabetes Society, in an interview with Medscape’s Portuguese edition.
“When discussing remission, it’s crucial to differentiate between temporary control from a real reversal of the disease,” he added.