Background and goal: The PROgramme of Lifestyle Intervention in Families for Cardiovascular risk reduction (PROLIFIC) Study, conducted in India, aimed to assess whether a family-based approach to lifestyle interventions could improve weight management and obesity-related health outcomes among individuals with a family history of premature coronary heart disease.
Study approach: In this cluster randomized controlled trial, families were randomly assigned to a family-based intervention group or a usual care group. The intervention group received structured lifestyle counseling from nonphysician health workers, who provided regular home visits, goal-setting, and peer group sessions focused on diet, physical activity, and cardiovascular health. The usual care group received one-time counseling and annual…