Introduction
Lung cancer has a major impact on public health, ranking first in the world’s cancer-related deaths.1 Lung adenocarcinoma (LUAD) is the most prevalent lung cancer with the very poor 5-year survival rate.2 Although improvements have been made in molecular diagnosis, most patients present with locally advanced or distant metastasis, which further contribute to poor prognosis.3,4 Therefore, knowledge of promising biomarkers is urgently needed to guide diagnosis and treatment.
Human Tripartite motif-containing (TRIM) proteins are composed of three characteristic structures and play an important role in carcinogenesis and immune regulation.5 Importantly, previous studies have demonstrated that TRIM proteins act as crucial regulators for cell growth, metabolism,…