Introduction
One’s diet, including the timing, quantity, and composition of foods consumed, has powerful effects on health. For example, diet directly affects body composition, makes key nutrients available to vital bodily functions, and affects systemic inflammation.1,2 Diet also affects health indirectly via interactions with activity and sleep behaviors.3–5 Of particular interest to the scientific community is the potential for dietary caloric restriction (CR), independent of weight loss and other factors, and alternative strategies such as time restricted eating (TRE) to enhance longevity in humans.6–18 Herein we present the design of the behavioral interventions underlying the Healthy Aging and Late Life Outcomes-Pilot (HALLO-P) trial involving CR and TRE,…