Researchers at the Ragon Institute have made a significant discovery about how antibodies can directly enhance the body’s ability to fight Mycobacterium tuberculosis (Mtb), the bacteria responsible for tuberculosis (TB). Despite decades of research, TB remains one of the deadliest infectious diseases worldwide, with about 10 million new cases and 1.6 million deaths annually. Currently, there is no highly effective vaccine, highlighting the urgent need for new insights and treatments.
In a study published today in Immunity, Ragon faculty member Galit Alter, PhD and previous post-doctoral trainee Patricia Grace, PhD, now at University of Pittsburgh, partnered with Bryan Bryson, PhD, associate member Sarah Fortune, PhD and a team of collaborators, to collect the largest library of monoclonal antibodies to…