A multi-center study led by researchers at Cincinnati Children’s sheds surprising new light on why some newborns become severely ill from Escherichia coli infection, but others do not. Turns out that most babies are immune because of germ-fighting antibodies they receive from their moms. The study, published March 11, 2026, in the prestigious journal Nature, … Read more
The COVID-19 pandemic brought messenger RNA (mRNA) vaccines to the forefront of global health care. After their clinical trial stages, the first COVID-19 mRNA vaccine was administered on 8 December 2020 and mathematical models suggest that mRNA vaccines prevented at least 14.4 million deaths from COVID-19 in the first year alone. Their extraordinary effectiveness in having … Read more
Announcing a new article publication for BIO Integration journal. Alzheimer’s disease (AD) is a neurodegenerative disorder and the leading cause of dementia worldwide. Microglia, as central nervous system (CNS) resident macrophages, are key to AD pathology. Indeed, microglia aggregation around amyloid-β (Aβ) deposits is an AD hallmark. Triggering receptor expressed on myeloid cells 2 (TREM2) … Read more
Researchers at örebro University have identified blood markers that can indicate who is at risk of developing ulcerative colitis – a chronic inflammatory bowel disease – later in life. These markers can be present for many years before the first symptoms appear. In the study, the researchers analysed blood samples from large population studies to … Read more
Among the most promising tools of cancer therapy, engineered immune cells known as chimeric antigen-receptor (CAR) T cells have already transformed the treatment of blood cancers. Yet, despite their promise, CAR-T cells do have their limitations. For one thing, they’ve so far largely failed against solid tumors, which is to say, most types of cancer. … Read more
A novel nasal booster approach may help close the gap between systemic vaccination and infection-blocking mucosal immunity, offering fresh insight into next-generation COVID vaccine strategies. Study: Intranasal booster drives class switching and homing of memory B cells for mucosal IgA response. Image Credit: Jo Panuwat D / Shutterstock Current intramuscular vaccines excel at eliciting blood-based … Read more
HIV-1 can be neutralized by antibodies which bind to vulnerable structures on the virus surface. One such vulnerable site is the so-called V3 glycan site of the viral envelope protein. This target structure plays a central role in virus entry into human cells and has therefore long been an important focus for the development of … Read more
A research team from POSTECH and ImmunoBiome in Korea, led by Professor Sin-Hyeog Im, has uncovered a new mechanism showing how butyrate-a short-chain fatty acid produced by gut commensal bacteria-enhances T follicular helper (Tfh) cell activity to promote antibody production and strengthen mucosal vaccine efficacy. This study identifies a new microbiota–immune–antibody production axis linking microbial metabolism … Read more
Australian researchers have developed a powerful new way to target deadly, drug-resistant bacteria by designing antibodies that recognize a sugar found only on bacterial cells – an advance that could underpin a new generation of immunotherapies for multidrug resistant hospital-acquired infections. Published in Nature Chemical Biology, the research shows that a laboratory-made antibody can clear … Read more
The lower hinge of immunoglobulin G (IgG), an overlooked part of the antibody, acts as a structural and functional control hub, according to a study by researchers at Science Tokyo. Deleting a single amino acid in this region transforms a full-length antibody into a stable half-IgG1 molecule with altered immune activity. The findings provide a … Read more