Biological differences between women and men led to variations in the appearance and progression of many diseases, which influenced diagnosis and response to treatments. These differences also affected the relationship between diseases, as they generated different combinations, risks, and patterns of joint appearance depending on sex. However, the biological mechanisms that explained these associations remained largely unexplored from a sex-differentiated perspective until now.
A new study led by the Barcelona Supercomputing Center – Centro Nacional de Supercomputación (BSC), in collaboration with researchers from the University of Valencia and the Catholic University of Portugal, published in Communications Medicine (Nature Portfolio), integrated sex for the first time as a key variable in the…