Fumitatsu Iwase and colleagues at Tokyo Medical University present a new inverse design strategy to enhance spatial confinement of topological π-modes in one-dimensional nonperiodic systems. The strategy addresses edge-mode penetration into the bulk of these systems, successfully generating potential sequences that exhibit a topological boundary layer and S-dense domain. This approach sharply improves confinement, achieving a localisation length of ξ=0.75 with a minimal two-block heterostructure, and offers a promising principle for designing strongly localised topological states. It provides a key set of tools for more compact quantum technologies and enables flexible designs for vital applications.