Announcing a new publication for Acta Materia Medica journal. Treatment of cancer can be challenging, because of the disease’s intricate and varied nature. Consequently, developing nanomedicines with multimodal therapeutic capabilities for precise tumor therapy holds substantial promise in advancing cancer treatment.
Herein, a nanoplatform strategy involving supramolecular photosensitizers (ETSCe6 NPs) and chelated metal ions (Au and Bi) was found to induce a shift in tumor microenvironment responsiveness from photothermal therapy to photodynamic therapy, thus facilitating tumor visualization for precise diagnosis and treatment. Self-assembly of supramolecular photosensitizers enhanced photothermal therapy through aggregation-caused quenching. Moreover, glutathione triggered disulfide bond cleavage, and…