Epigenetic memory of colitis promotes tumour growth

Animals and cell lines Animal work Mouse (Mus musculus) strains C57BL/6J (strain no. 000664) and Cdx2:CreERT2;APCfl/fl;KrasWT (strain no. 035169)50 were obtained from The Jackson Laboratory. Mice were housed at room temperature and ambient humidity in individually ventilated cages at a maximum density of five mice per cage with ad libitum access to food and water … Read more

Whole-Genome Sequencing in Cancer: Feasibility, Actionability & Impact on Survival

Archyde Recent advancements in whole-genome sequencing (WGS) are making significant strides in the clinical management of solid tumors. A comprehensive study involving 935 patients, conducted between January 2021 and November 2022, … Read More You can read the full story here: <p><strong>Whole-Genome Sequencing in Cancer: Feasibility, Actionability & Impact on Survival</strong></p>. Source link

Decoding the dark genome reveals its organisation into modular disease networks

Babar., U. Monogenic disorders: An overview. Int. J. Adv. Res. (Indore). 5, 1398–1424 (2017). Google Scholar  Cleynen, I. & Halfvarsson, J. How to approach understanding complex trait genetics – inflammatory bowel disease as a model complex trait. United European gastroenterology journal 7, 1426–1430 Preprint at (2019). https://doi.org/10.1177/2050640619891120 Apgar, T. L. & Sanders, C. R. Compendium … Read more