TOPLINE: Continuing metformin throughout the first trimester in women with polycystic ovary syndrome (PCOS) showed the potential to reduce miscarriage risk (odds ratio [OR], 0.64) and increase clinical pregnancy rates (OR, 1.57) compared with placebo. A meta-analysis of 12 randomized controlled trials involving 1708 women suggested that stopping metformin at pregnancy confirmation might be less … Read more
A sweeping new analysis reveals that the burden of female infertility has soared over the past three decades, with age-standardized rates rising and women in their late 30s facing the highest risk worldwide. Study: Global, regional, and national burden of female infertility and trends from 1990 to 2021 with projections to 2050 based on the … Read more
The American Society of Clinical Oncology (ASCO) has released updated guidelines to guide fertility preservation for people with cancer, with the previous update published in 2018. The 2025 update reflects substantial growth in the evidence base, with 166 studies incorporated compared with just 61 studies in the 2018 guidelines. According to the authors, this expanded … Read more