Canada Targets PCPs With New Hypertension Guideline

Hypertension Canada has released a guideline that aims to enhance the standard of hypertension management in primary care settings with evidence-based, pragmatic, and easy-to-implement recommendations. The guidance is based on the World Health Organization’s HEARTS framework to improve hypertension control and reduce cardiovascular burden. The previous guideline was published in 2020. “For the 2025 guideline, … Read more

NICE Approves Sparsentan for Kidney Disease Treatment

The National Institute for Health and Care Excellence has recommended sparsentan (Filspari, Vifor Pharma) for treating primary immunoglobulin A nephropathy in adults. The recommendation reverses NICE’s February decision to reject NHS funding for the drug. The regulator had previously said available evidence did not demonstrate value for money. The manufacturer provided additional analyses and agreed to … Read more

S3 Episode 5: Managing Type 2 Diabetes and CKD: SGLT2 Inhibitors vs GLP-1s

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Carol H. Wysham, MD: Hello. I’m Dr Carol Wysham. Welcome to season 3 of the Medscape InDiscussion Type 2 Diabetes podcast series. Today, we’ll discuss chronic kidney … Read more

Maternal Preeclampsia Tied to Kidney Disease Risk in Kids

TOPLINE: Children exposed to maternal preeclampsia and born at term (37 weeks or more) were 26% more likely to develop kidney disease in the first year of life than those not exposed. They also faced notably high risks for chronic, unspecified, and diabetic kidney diseases as they grew older, particularly at or after 25 years … Read more

Sotagliflozin: Lower A1c & Weight, Even with Kidney Issues

Sotagliflozin Shows Promise for Diabetes Management,Despite FDA Hurdles New research presented at the American Association of clinical Endocrinology (AACE) Annual Meeting 2025 suggests that sotagliflozin (Inpefa) can lower A1C levels and reduce body weight in individuals wiht type 2 diabetes. However, the benefits appear to be less pronounced in patients with moderate-to-severe chronic kidney disease … Read more

Acute Kidney Injury Tied to Poor Outcomes in Hospitals

TOPLINE: A substantial proportion of patients admitted to hospitals in Italy experienced acute kidney injury (AKI), which was associated with worsened in-hospital mortality outcomes, longer hospital stays, and more frequent admissions to intensive care units (ICUs). METHODOLOGY: Researchers conducted a retrospective observational study to examine the incidence of AKI in two Italian university hospitals from … Read more

GPs Lead the Way in Home-Based Albuminuria Screening

TOPLINE: Systematic home-based screening for albuminuria in primary care identified previously undiagnosed risk for chronic kidney disease (CKD), with greater participation among individuals invited by general practitioners (GPs). Overall, 8.7% of GP-invited participants had confirmed increased albuminuria, with 40.6% of them being newly diagnosed. METHODOLOGY: Researchers conducted a cross-sectional screening study to evaluate the effectiveness … Read more

Sparsentan Provides Better Proteinuria Reduction in FSGS

BOSTON — Sparsentan, a first-in-class, oral dual endothelin-angiotensin receptor antagonist, shows significant benefit in reducing proteinuria in the difficult-to-manage focal segmental glomerulosclerosis (FSGS) compared with the angiotensin II receptor blocker (ARB) irbesartan, a new post-hoc analysis of the phase 3 DUPLEX trial shows. “Dual endothelin angiotensin receptor blockade with sparsentan led to partial or complete … Read more

7 Habits That Could Be Damaging Your Kidneys

In the UK, more than  is estimated to have some stage of chronic kidney disease and more than  develop some form of  — when the kidneys suddenly stop working properly but can recover — each year. The kidneys play a vital role in maintaining overall health by filtering waste, excess fluids and electrolytes, such as sodium and potassium, … Read more