The dynamic basis of G-protein recognition and activation by a GPCR

Hilger, D., Masureel, M. & Kobilka, B. K. Structure and dynamics of GPCR signaling complexes. Nat. Struct. Mol. Biol. 25, 4–12 (2018). Article  CAS  PubMed  PubMed Central  Google Scholar  Herrera, L. P. T. et al. GPCRdb in 2025: adding odorant receptors, data mapper, structure similarity search and models of physiological ligand complexes. Nucleic Acids Res. … Read more

A large-scale coherent 4D imaging sensor

Design and fabrication Photonic device and circuit-level simulations were performed using ANSYS Lumerical tools, whereas the integrated electronics followed a design flow using Cadence Virtuoso. The finalized design was verified against the design rules using Cadence’s Physical Verification System (PVS). The demonstrated integrated monostatic FPA was fabricated using GlobalFoundries’ 45SPCLO 300-mm silicon photonics platform, which … Read more

Intestinal interoceptive dysfunction drives age-associated cognitive decline

Mice Unless noted otherwise, young female (8 weeks old) and male (4 weeks old) C57BL/6 mice were obtained from The Jackson Laboratory and old mice (18 months old) were acquired from the National Institute on Aging. For co-housing, mice were housed either two young + three old, or three young + two old per cage. Males were co-housed before … Read more

FMCL: a transformer-based feature-map classifier learning approach for enhanced brain tumor detection in MRI

Yao, Q., Zhuang, D., Feng, Y., Wang, Y. & Liu, J. Accurate detection of brain tumor lesions from medical images based on improved YOLOv8 algorithm. IEEE Access 12, 144260–144279 (2024). Google Scholar  Farnoosh, R. & Noushkaran, H. Development of an unsupervised pseudo-deep approach for brain tumor detection in magnetic resonance images. Knowl. Based Syst. 300, … Read more

A novel strut injector with lateral extruded nozzle for efficient hydrogen mixing in supersonic combustors

Li, Z. et al. Nusier. Influence of lateral injection from the circular strut on mixing performance of hydrogen jet at supersonic combustion chamber. Int. Commun. Heat Mass Transfer. 140, 106543 (2023). Google Scholar  Gerdroodbary, M. B. Aerodynamic Heating in Supersonic and Hypersonic Flows: Advanced Techniques for Drag and Aero-Heating Reduction 1st edn (Elsevier, 2022). Google … Read more

Narrower jugular bulbs and their tributaries are associated with skull base venous hyperintensity on arterial spin-labeling MRI

Lindner, T. et al. Current state and guidance on arterial spin labeling perfusion MRI in clinical neuroimaging. Magn. Reson. Med. 89, 2024–2047 (2023). Google Scholar  Haller, S. et al. Arterial spin labeling perfusion of the brain: Emerging clinical applications. Radiology 281, 337–356 (2016). Google Scholar  Iwamura, M. et al. High-signal venous sinuses on MR angiography: … Read more

Monthly HIV-drug injections offer potent alternative to daily tablets – Nature

Monthly HIV-drug injections offer potent alternative to daily tablets  Nature New antiretrovirals in the pipeline could be part of twice-yearly HIV treatment  Aidsmap [CROI 2026] aidsmap: New antiretrovirals in the pipeline could be part of twice-yearly HIV treatment  European AIDS Treatment Group Source link

Modeling roles and trade-offs in multiplex networks

Jalili, M., Orouskhani, Y., Asgari, M., Alipourfard, N. & Perc, M. Link prediction in multiplex online social networks. R. Soc. Open Sci. 4, 160863 (2017). Google Scholar  Atkisson, C., Górski, P. J., Jackson, M. O., Hołyst, J. A. & D’Souza, R. M. Why understanding multiplex social network structuring processes will help us better understand the … Read more

A proof of concept study on the diagnostic utility of in vivo expressed mycobacterial transcripts in tuberculous pleuritis

WHO. Global TB report 2021. (Accessed Dec 2021) http://www.who.int (WHO, 2021). Cascio, C., Kaul, V., Dhooria, S., Agrawal, A. & Chaddha, U. Diagnosis of tuberculous pleural effusions: A review. Respir Med. 188, 106607 (2021). Google Scholar  Bielsa, S., Acosta, C., Pardina, M., Civit, C. & Porcel, J. M. Tuberculous pleural effusion: Clinical characteristics of 320 … Read more