NIH funds AI project to advance Alzheimer’s research and treatment

The National Institutes of Health has renewed support for Artificial Intelligence for Alzheimer’s Disease, or AI4AD. The new $12.6 million award to advance the project’s next phase, AI4AD2, brings its total investment in AI4AD to $30.7 million. Led by Paul M. Thompson, PhD, associate director of the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) … Read more

Stroke may trigger younger brain patterns in unaffected regions

In a new study published in The Lancet Digital Health, scientists at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) have discovered that the brains of people who experience severe physical impairment after a stroke may reorganize themselves in unexpected ways, showing signs of “younger” brain structure in undamaged regions as they adapt to injury. … Read more

Exposure to nature reduces negative emotions and boosts brain capital

You probably heard it from your mom a thousand times – fresh air and sunshine; it’s the cure for most anything. Now scientists at the University of Houston concur, measuring the impact of mother’s advice on mother nature to find that exposure to nature is associated with reductions in negative emotions.  Given that nearly 90% of the U.S. population is projected … Read more

Iconeus expands U.S. presence to support growing adoption of fUS in preclinical brain imaging

Iconeus, a French neuroimaging company developing functional ultrasound (fUS) solutions for real-time brain activity imaging, today announced the creation of its U.S. entity, Iconeus Inc. – a key milestone in supporting the adoption of functional ultrasound in preclinical neuroscience research. The new U.S. presence will enable closer collaboration with American academic laboratories, research institutes, pharmaceutical … Read more

Study reveals racial differences in early Alzheimer’s brain changes

A team of researchers at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC has identified important differences in how early Alzheimer’s disease-related brain changes appear across racial and ethnic groups, underscoring the need for more inclusive approaches to studying and diagnosing the disease. … Read more

New review calls for biologically grounded approach to psychiatric diagnosis

A comprehensive invited review published today in Brain Medicine confronts one of the most persistent paradoxes in modern medicine: psychiatry remains the only major clinical discipline that diagnoses complex illness primarily through conversation and symptom checklists, while fields such as oncology and cardiology long ago embraced laboratory markers, imaging, and molecular profiling. The review, authored … Read more

Narrower jugular bulbs and their tributaries are associated with skull base venous hyperintensity on arterial spin-labeling MRI

Lindner, T. et al. Current state and guidance on arterial spin labeling perfusion MRI in clinical neuroimaging. Magn. Reson. Med. 89, 2024–2047 (2023). Google Scholar  Haller, S. et al. Arterial spin labeling perfusion of the brain: Emerging clinical applications. Radiology 281, 337–356 (2016). Google Scholar  Iwamura, M. et al. High-signal venous sinuses on MR angiography: … Read more

Protein linked to Parkinson’s may drive faster Alzheimer’s disease progression in women

Alzheimer’s-related brain changes progressed up to 20 times faster in women who also had abnormal levels of a Parkinson’s-related protein, according to a Mayo Clinic study published in JAMA Network Open. The same pattern was not observed in men. The findings suggest that when alpha-synuclein – a protein linked to Parkinson’s disease – accumulates alongside Alzheimer’s pathology, … Read more

Nature reduces stress by shifting brain activity

From alpha brain waves to amygdala activity, scientists map how forests, wetlands, and even immersive virtual nature can recalibrate the brain, revealing why stepping outside may be one of the most powerful tools for mental resilience. Study: Your brain on nature: A scoping review of the neuroscience of nature exposure. Image credit: PeopleImages/Shutterstock.com A recent … Read more

Machine learning predicts who will decline faster in Alzheimer’s disease using routine clinic data

By harnessing everyday clinical assessments, researchers demonstrate that personalized 12-month forecasts of cognitive and functional change in dementia can be achieved without expensive imaging or invasive testing. Study design and analysis pipeline. Clinical assessments are collected at regular intervals throughout the Minder study (a), features used for statistical analysis and predictive modelling included clinical assessment … Read more