Microbiome dysbiosis—changes in the composition of gut microbes that alter the metabolites present—has long been implicated in playing a causative role in the pathophysiology of autism spectrum disorder (ASD). However, the changes in the gut microbial metabolites that are associated with ASD-specific brain alterations have remained unknown. Now, a new study suggests that gut microbiome … Read more
Cancer diagnoses traditionally require invasive or labor-intensive procedures such as tissue biopsies. Researchers at the Ludwig-Maximilians-Universität München (LMU) have now reported on a method that uses pulsed infrared light to identify molecular profiles in blood plasma that could indicate the presence of some common cancers. In a proof-of-concept study, the team used machine learning to … Read more
Scientists from the Allen Institute and Seattle Children’s Research Institute have announced a breakthrough in the development of gene replacement therapies for Dravet syndrome, a rare form of epilepsy. According to details published in a Science Translational Medicine paper, mice treated with the new therapy survived and had alleviated symptoms and long-term recovery without toxicity … Read more
By analyzing single-cell and spatial transcriptomic data from myeloid cells from 85 brain tumors, scientists from McGill University, the Broad Institute, and elsewhere found that a commonly prescribed anti-swelling drug, dexamethasone, suppresses the immune system for weeks after dosing, inhibiting its response to the cancer. The findings could open a door to more effective strategies … Read more
Broadcast Date: Wednesday, April 9, 2025 Time: 8:00 am PT, 11:00 am ET, 17:00 CEST Product safety and efficacy is an integral part of conversations about the potential of cell and gene therapies, particularly when compared to traditional drug products like small molecules. The presence of visible and subvisible particles is a major indicator of … Read more
While working on a COVID-19-related project during the lockdown, Kärt Tomberg, PhD, found herself thinking about introns. She was part of a team working on the spike protein used in vaccines. Her task was to make the expression construct for the protein. “I’m a geneticist and I’d been looking at genes for 19 years but … Read more
Archyde Decoding Dreams: Insights from a Somnium Specialist Table of Contents 1. Decoding Dreams: Insights from a Somnium Specialist 2. Common Dream Themes and Their Symbolic Meanings 3. Unlocking the Secrets of Your Dreams: Practical Tips for Interpretation 4. The Power of Self-Finding Through Dreams 5. Unlocking Self-Knowledge through Dreams 6. Expert Insights on Dream … Read more
Whole genome sequencing (WGS) is not necessarily a solution for someone with a rare, monogenic disease. Indeed, more than half of families with suspected rare monogenic diseases do not have an answer after WGS when short-read sequencing is performed. Now, a group of researchers present data that suggests that long-read sequencing may be the better … Read more
New research from scientists at the University of Washington (UW) School of Medicine and Duke University describes how cellular RNA helps regulate antiviral signaling as part of the immune response against viral infections. Details are published in a new Science paper titled, “Cellular RNA interacts with MAVS to promote antiviral signaling.” The scientists say that … Read more