Salk Institute

Rockefeller University Scientists Find Tuberculosis Mutation’s ‘Weak Point

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Exploiting the Evolutionary Trade-offs of Tuberculosis

Researchers at the Rockefeller University and the Salk Institute have identified biological mechanisms that turn drug resistance into a vulnerability for pathogens and cancer cells. By exploiting the evolutionary trade-offs inherent in bacterial mutations and cancer cell diversity, scientists aim to develop combination therapies that effectively trap these threats in a state of increased susceptibility … Read more

New Breakthrough Could Prevent Muscle Loss While Shedding Pounds

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The stomach sends hunger signals to the brain in the form of ghrelin (blue arrow), prompting the brain to send growth hormone to muscle tissue (pink line). In the foreground, a closer look at the muscle reveals growth hormone (pink orbs) influencing BCL6 (purple blob) to attach to the cell’s DNA (purple chain), where it … Read more