Statistics for Life Sciences

Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): statistical analysis plan for a randomised controlled trial | Trials

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Trial design OPTIMAS is a large, prospective, partially blinded randomised controlled trial of early (within ≤ 4 days [96 h]) or standard (between day 7 and day 14 after stroke onset) initiation of anticoagulation after stroke in patients with AF, using any licensed dose of a DOAC. Randomisation An independent, concealed, online randomisation service (www.sealedenvelope.com) will be used to … Read more

Comparison of the effects of transcranial direct current stimulation and transcutaneous tibial nerve stimulation on the urgency and frequency of women with overactive bladder syndrome: study protocol of a randomized clinical trial | Trials

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Research sites The study will be conducted at the Neuromusculoskeletal Research Center, Firoozgar Hospital. Ethics This research is a superiority trial aiming to demonstrate that tDCS is more effective than PTNS in improving urinary continence and reducing symptoms of OAB. The study has been approved by the Tehran University of Medical Sciences Ethics Committee in … Read more

Artificial intelligence methods applied to longitudinal data from electronic health records for prediction of cancer: a scoping review | BMC Medical Research Methodology

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Retrieved studies Searching the 6 databases returned 1214 studies, of which 414 were duplicates. A further 61 studies were retrieved from reference and citation searches. Following screening and eligibility assessment, 35 studies were included in the final review. A flowchart showing the selection process is provided in Fig. 2. The number of studies published by … Read more

SQUARE-IT: a proposed approach to square the identified research problem in the literature with the objectives, the appropriate clinical research question, and the research hypothesis | BMC Medical Research Methodology

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The item ‘Specific’ of the SQUARE-IT approach asks whether there is a specific, obvious, explicit, relevant and unambiguous research problem/gap in literature or clinical practice regarding the research topic. The identification of a clear and unambiguous problem to be investigated is a crucial step in establishing a research agenda [22]. The identified problem, which may … Read more

Development and validation of a model to identify polycystic ovary syndrome in the French national administrative health database | BMC Medical Research Methodology

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Preliminary study: identifying women with PCOS using ICD-10 code E28.2 in the French National Health Data System The French National Health Data System “Système National des données de Santé” (SNDS) is a national database that contains a wide range of health-related information. SNDS database covers nearly the entire French population (98.8%), which accounted for more … Read more

Effect of transcutaneous electro-stimulation in postoperative rehabilitation pain treatment in thoracic surgery: a randomized clinical trial | Trials

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Liu CW, Page MG, Weinrib A, Wong D, Huang A, McRae K, et al. Predictors of one year chronic post-surgical pain trajectories following thoracic surgery. J Anesth. 2021;35(4):505–14. Article  PubMed  Google Scholar  Peng Z, Li H, Zhang C, Qian X, Feng Z, Zhu S. A retrospective study of chronic post-surgical pain following thoracic surgery: prevalence, … Read more