A new Cochrane review confirmed that antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and serotonin-noradrenaline reuptake inhibitors (SNRIs), are superior to placebo in adults with generalized anxiety disorder (GAD) and have comparable study dropout rates. However, the long-term impact of antidepressants on GAD remains unclear.
“We have high confidence that antidepressants are more effective than placebo at improving treatment response and that antidepressants have similar acceptability to placebo,” the authors, led by Katarina Kopcalic, MSc, Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada, wrote.
The findings were published on January 30 in the Cochrane Database of Systematic Reviews.
Common, Debilitating Disorder
GAD is a common condition and…