A recent international research project has used advanced microscopy techniques and computational modeling to discover why virus infection changes the nuclear structures and biomechanical forces affecting the nucleus.
Researchers at the University of Jyväskylä (Finland), in cooperation with national and international research groups, have shown that DNA viruses infect cells and take over the host cell nucleus induce dramatic structural modifications. Herpes simplex virus 1 (HSV-1) infection and the emergence of nuclear enlarged, low-density viral replication compartments lead to changes in nuclear volume, chromatin organization, and the structure of nuclear lamina.
Understanding the softening of the nucleus enables early diagnosis
Researchers show that the infection remodels nuclear biomechanics,…