Top early-life factors driving childhood food allergy

A sweeping analysis of nearly three million children pinpoints which early-life factors most strongly predict food allergy risk, revealing how skin barrier health, family history, and early exposures intersect to shape outcomes. Study: Risk Factors for the Development of Food Allergy in Infants and Children. Image credit: Alona Siniehina/Shutterstock.com A systematic review and meta-analysis of … Read more

New Data Backs Use of Milk and Egg Ladders in Severe IgE-Mediated Food Allergies

Credit: Adobe Stock/ Pixel-Shot A case series shows the safety and efficacy of the 5-step milk ladder and 4-step egg ladder in building tolerance among children at high risk with severe immunoglobulin E (IgE)-mediated cow’s milk and hen’s egg allergies.1 “This retrospective case-series of 29 children…. provided evidence that the 5- [milk ladder] and the … Read more

Diphenhydramine Emergency Department Trends Show No Shift Since 2019

Credit: Adobe Stock/ Chinnapong A study observed unchanged emergency department practices regarding diphenhydramine for anaphylaxis and urticaria despite 2020 guidelines discouraging using first-generation antihistamines.1 At least 1.6% of the general population experiences an anaphylaxis reaction, with this proportion rising. There has also been an increase in anaphylaxis cases treated in the emergency department, comprising 0.4% … Read more

NSAIDs, H2 Blockers, and Penicillin Linked to Greater Anaphylaxis Risk from Mild Drug Reactions

Credit: Adobe Stock/ Kwangmoozaa A study identified non-steroidal anti-inflammatory drugs (NSAIDs), H2 blockers, and penicillin as risk factors for anaphylaxis evolving from a non-severe drug hypersensitivity reaction.1 The study also showed that the intravascular route was associated with a lower risk of the progression of non‐severe hypersensitivity reactions to anaphylaxis. “[This] may be attributed to … Read more

Anaphylaxis Severity Rises With Age in Emergency Care

TOPLINE: Older adults who present to the emergency department (ED) with anaphylaxis may be more likely than younger adults to be hospitalized and to have medications or intravenous contrast as triggers, a study showed. Older patients also may be less likely to receive epinephrine from emergency medical services (EMS). METHODOLOGY: Researchers examined data from ED … Read more

CDC confirms black-legged ticks can cause red meat allergy in humans

A woman in Maine developed a dangerous meat allergy after a black-legged tick bite—prompting the CDC to rethink which ticks can trigger alpha-gal syndrome. A decade of cases suggests the threat is broader than once believed. Dispatch: Alpha-Gal Syndrome after Ixodes scapularis Tick Bite and Statewide Surveillance, Maine, USA, 2014–2023. Image Credit: Aleksei Ruzhin / Shutterstock In … Read more