BRCA

Breast-Conserving Tx, Mastectomy Have Similar Outcomes

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TOPLINE: In a multicenter cohort study of 575 South Korean patients with BRCA1 or BRCA2 pathogenic variants, breast-conserving treatment demonstrated comparable oncologic outcomes to mastectomy over a median follow-up of 8.3 years. After propensity score matching, no significant differences between the two surgical approaches were found in terms of locoregional recurrence, distant recurrence, and overall … Read more

Risk-Reduction Surgery Benefit in Non-BRCA Ovarian Cancer?

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BOSTON — Patients with non-BRCA gene mutations undergoing risk-reduction surgery to prevent tubo-ovarian cancers showed no signs of tubo-ovarian high-grade serous carcinoma or serous tubal intraepithelial carcinoma compared with about 3% incidence of these carcinomas in patients with BRCA mutations in a multi-center study. “We need to define the role of risk-reduction surgery in reducing … Read more