Cholelithiasis

Acute Cholecystitis: Non-Operative Management vs Surgery

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TOPLINE: Among patients with acute cholecystitis who were managed non-operatively, 38.3% experienced new complications. Delayed cholecystectomy was recommended for younger patients with prior complications. METHODOLOGY: Researchers conducted a retrospective study to identify risk factors for gallstone disease relapse and establish the timeline for recurrence. They included 1634 patients treated for acute cholecystitis at three Swedish … Read more

Targeting PCSK9 and APOA4 for the treatment of TMAO-induced cholelithiasis

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Background and aims Cholesterol synthesis and gallstone formation are promoted by trimethylamine-N-oxide (TMAO), a derivative of trimethylamine, which is a metabolite of gut microbiota. However, the underlying mechanisms of TMAO-induced lithogenesis remain incompletely understood. This study aimed to explore the specific molecular mechanisms through which TMAO promotes gallstone formation. Methods Enzyme-linked immunosorbent assays were used … Read more