Gene Expression

How could bisphenol A raise depression risk? Study identifies six key molecular targets

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Researchers combined genetic epidemiology, transcriptomics, molecular docking, and mouse experiments to show how a common endocrine-disrupting chemical may influence biological pathways tied to major depressive disorder. Study: Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation. Image Credit: monticello / Shutterstock A new study … Read more

Alcohol impacts gene expression differently across brain regions

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Erica Periandri and Gabor Egervari, from Washington University in St. Louis, led a study to explore how alcohol exposure in male mice influences gene expression and mechanisms that regulate gene function-or epigenetics. Says Egervari, “We recently uncovered that metabolites [from the body’s breakdown] of alcohol directly regulate genes in the hippocampus following a one-time exposure to alcohol. This is a previously unknown and surprisingly direct way in which alcohol impacts the brain, and it … Read more

Heart failure and atrial fibrillation share underlying genetic and molecular mechanisms

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New research published in Nature Cardiovascular Research reveals that heart failure and atrial fibrillation share underlying genetic and molecular mechanisms, suggesting that the two cardiovascular conditions may be less distinct than previously thought. Two serious heart conditions that often coexist Heart failure occurs when the heart muscle is damaged and unable to pump enough nutrient-rich blood to meet the … Read more

Chronic inflammation leaves epigenetic scars that increase future cancer risk

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Chronic inflammation can raise a person’s risk of cancer, and a new study reveals key details about how that might happen in the gut and points to better ways to identify and reduce risk. Scientists at the Broad Institute and Harvard University have revealed in mice that after colitis, or chronic intestinal inflammation, seemingly healed … Read more

Study sheds light on potential therapeutic strategies for post-traumatic osteoarthritis

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Post-traumatic osteoarthritis often affects younger, active individuals and progresses quickly following ligament or cartilage injury. Chondrocytes, the sole cell type in articular cartilage, survive in a low-oxygen environment by relying heavily on glycolysis, producing large amounts of lactate. While lactate has traditionally been associated with tissue stress and inflammation, emerging evidence suggests it also functions … Read more

New HIV-seq tool advances understanding of persistent viral reservoirs

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For people living with human immunodeficiency virus (HIV), life-saving antiretroviral therapy keeps their HIV-infected immune cells from making new copies of the virus, preventing illness and transmission. Historically, these infected cells have been known as the “latent” HIV reservoir-implying that the HIV within the infected cells is completely inactive. But notion that the entirety … Read more

A comparative anti-proliferative and immunomodulatory analysis in wild and lab-acclimatized seaweed extracts unravel the functional biopotentials of Acrosiphonia orientalis

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Choudhary, B., Chauhan, O. P. & Mishra, A. Edible seaweeds: a potential novel source of bioactive metabolites and nutraceuticals with human health benefits. Front Mar. Sci 8, 740054 (2021). Mishra, A. Algal Functional Foods and Nutraceuticals: Benefits, Opportunities, and Challenges (Bentham Science, 2022). Baghel, R. S. et al. Rehashing our insight of seaweeds as a … Read more

A multi-dimensional framework for establishing and managing a genomic newborn screening program

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The above-described methodology resulted in a multi-dimensional framework for a gNBS program consisting of 18 screening criteria (Table 1) assigned to two overarching categories and four subcategories: (A) Criteria that enable transparent disease selection: I. Four clinical criteria, II. Four diagnostic criteria, and III. Three therapeutic-interventional criteria … Source link

Study maps how NF-κB regulates gene expression in cells

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To further the quantitative understanding of cellular decision making, Dr. Gregory Reeves and his team in the chemical engineering department have worked to interpret how a transcription factor dictates the alteration of gene expression in cells.  The team’s work, recently published in Science Advances, focuses on a protein called Dorsal, which is a version of nuclear factor-κB (NF-κB) – … Read more

NIH’s continued investment fuels TMJ pain research

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Chronic pain is one of the most common health conditions worldwide. Back pain is the most frequently reported type, followed closely by head and face pain linked to the jaw joint, in the form of temporomandibular joint (TMJ) disorder. While not life-threatening like cancer or infectious disease, chronic pain can dramatically diminish quality of life … Read more