Credit: Danie Franco/Unsplash A network meta-analysis linked treatment with sodium-glucose co-transporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) to a lower risk of major adverse cardiovascular events (MACE) in people with type 2 diabetes (T2D), citing interactions by age and sex.1 This review of 601 trials, involving individual participant data from 103 … Read more
Diego Bagnasco, MD, PhD Credit: Research Gate Inhaled triple therapy (ITT), despite being well known to decrease exacerbation rate and improving lung function for patients with asthma, was still not widely used by clinicians due to uncertainty in implementing it into patients’ treatment regimens.1 “Despite [previous] evidence2… ITT is not used enough in patients with … Read more
Novo Nordisk has completed a phase 2 trial of monlunabant, formerly INV-202, in patients with diabetic kidney disease, according to a 2024 financial report from the company.1 As detailed in the February 5, 2025, press release, the trial investigated the efficacy and safety of a once-daily 10 mg and 25 mg dose of monlunabant, a … Read more
Perceived stress was positively correlated with symptom burden in people with fibromyalgia syndrome even when not correlated with endocrinological stress indicators, according to new research.1 “As chronic stress-associated conditions and chronic pain have been associated with a suppression of hypothalamic-pituitary-adrenal (HPA)-activity, we postulate that people with FMS will have subjectively elevated stress levels compared to … Read more
Kasia Lipska, MD, MHS Credit: Yale It is commonly known that having type 2 diabetes can lead to the development of various health conditions, including heart disease, neuropathy, kidney disease, and eye disease. Not as well-known is the association between type 2 diabetes and infection, according to Kasia Lipska, MD, MHS, who recently published a … Read more
Welcome back to New Insight with Veeral Sheth, MD! Key Episode Timestamps 00:05 Introduction to Elad Kedar and Orasis 04:34 Orasis’ Journey and Initial Development 06:45 Elad Kedar’s Background and Company Growth 08:36 Transition from Product Development to Team Building 11:42 Phase Three Study Results and Efficacy 13:39 Safety, Comfort, and Tolerability 15:00 Genesis of … Read more
Justin Steggerda, MD Credit: Cedars-Sinai New research is shedding light on inequities posed by the “pediatric advantage” of current kidney transplant allocation policies, which disadvantage patients who initiated dialysis as children but were not waitlisted until after 18 years of age.1 Leveraging waitlist registration and transplant outcome data from the OPTN Standard Transplant and Research … Read more
Michael Kueht, MD Credit: University of Texas Medical Branch Donor hepatitis C virus (HCV) positivity does not negatively impact 1-year rejection and mortality outcomes following renal transplantation in HCV-negative recipients, according to findings from a recent study.1 The retrospective, propensity score-matched case-control study leveraged data from the TriNetX US Collaborative Network and found donor HCV … Read more
Archyde The use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for treating type 2 diabetes (T2D) is rapidly increasing globally, driven by the rising prevalence of T2D adn obesity. these medications have proven benefits for cardiovascular health, kidney function, and reducing fatty liver disease. However, concerns have been raised about a potential link between GLP-1 … Read more
Victor Mocanu, MD Credit: Research Gate People with psoriatic arthritis (PsA) and ankylosing spondylitis (AS), particularly in rural settings, frequently utilized emergency departments (Eds) for less and non-urgent health concerns, highlighting the need for more accessible health services in these areas.1 “Greater accessibility to ambulatory services may mitigate emergency department (ED) presentations for lower acuity … Read more