NIH funds AI project to advance Alzheimer’s research and treatment

The National Institutes of Health has renewed support for Artificial Intelligence for Alzheimer’s Disease, or AI4AD. The new $12.6 million award to advance the project’s next phase, AI4AD2, brings its total investment in AI4AD to $30.7 million. Led by Paul M. Thompson, PhD, associate director of the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) … Read more

Large study links more siblings to better bereavement coping

Having more brothers and sisters may make it easier to cope with the death of a parent, in midlife, particularly when it’s the mother who dies, suggests research published online in the Journal of Epidemiology & Community Health. Fewer mental health drugs are bought by those with more siblings, especially women, in the aftermath of a … Read more

Study reveals how extracellular matrix stiffness regulates breast cancer metastasis

A study by researchers at the University of California San Diego could make it easier to treat breast cancer by uncovering a new way the body helps prevent its spread. The scientists discovered a new role for an inflammatory protein called TYK2 in mechanotransduction, the process by which cells sense and respond to their physical … Read more

New neural organoid system improves scalability and reproducibility for research

Neural organoids have been heralded as having huge potential for advancing our knowledge of the brain in several fields. These include exploring the responses of brain tissue to drugs, investigating the effect of specific genetic mutations on neural electrical activity and characterising how neural systems develop.  In the past, viability of these systems has been limited by their scalability, reproducibility and longevity.  New research from King’s College London has succeeded in scaling up the organoid approach; … Read more

Diverse biobank study links genetics to disease risk and treatment

A new study by UCLA Health published in Cell presents a major advancement in the future of personalized medicine by pinpointing new connections between people’s genes, disease risk and medicine response by using a clinically well-characterized and diverse population-represented biobank. By analyzing genetic data and electronic health records from 93,936 participants in the UCLA ATLAS … Read more

Drugs targeting TIE2 protein could help prevent formation of cerebral cavernous malformations

Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a cell surface receptor protein called TIE2 as the missing link between two key signaling pathways that drive the growth of blood vessel abnormalities known as cerebral cavernous malformations (CCMs). The study, to be published March 27 in the Journal of … Read more

GLP-1 medications show mixed effects on body contouring outcomes

For patients undergoing body contouring surgery to remove excess abdominal skin after massive weight loss, use of GLP-1 weight-loss medications may have mixed effects on complication risks, suggests a study in the April issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). The journal is published in the Lippincott portfolio by Wolters Kluwer. “As GLP-1 receptor agonist [GLP1ra] medications become increasingly integrated into the care … Read more

Estradiol patches as effective as injections for locally advanced prostate cancer

Hormone patches are as good at controlling locally advanced prostate cancer as the injections typically used to deliver hormone therapy, according to the results of a large clinical trial led by UCL (University College London) researchers. Men with cancer that has spread just outside the prostate are given hormone therapy to suppress levels of testosterone which … Read more

iXCells Biotechnologies joins international collaboration to evaluate chemotherapeutic toxicity in human organoids

iXCells Biotechnologies (“iXCells”), a leading provider of human cell-based solutions and custom iPSC services, today announced it has entered an international collaboration with Rosebud Biosciences (“Rosebud”), Kantify, and Incite to evaluate off-target chemotherapeutic toxicities in patient-specific organoids. Building on iXCells’ recent partnership with Rosebud and funded by Incite, the project will initially focus on predicting … Read more