NARTIs

Certain HIV Meds Linked to Reduced Alzheimer’s Risk

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TOPLINE: Use of nucleoside reverse transcriptase inhibitors (NRTIs), but not other medications for HIV, was associated with a significantly reduced risk for Alzheimer’s disease (AD) in an analysis of two national databases. NRTIs are antiretroviral drugs that block the activation of inflammasome. METHODOLOGY: This study included data of nearly 272,000 US individuals from two national … Read more

Switching to Three-Drug Regimen Maintains HIV Suppression

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TOPLINE: Switching from a boosted protease inhibitor (bPI)–based regimen to bictegravir plus emtricitabine plus tenofovir alafenamide (B/F/TAF) maintained virological suppression over 48 weeks in patients with HIV who had preexisting resistance to nucleoside reverse transcriptase inhibitors (NRTIs), however with increased adverse events.  METHODOLOGY: This phase 4 trial assessed the safety and efficacy of switching from … Read more