Study reveals how a promising bacterial therapy reduces recurrent bacterial vaginosis

A new study from the Kwon Lab at the Ragon Institute, published in Cell Host & Microbe, provides the most detailed picture yet of how a promising bacterial therapy works to prevent recurrent bacterial vaginosis (BV) and why it works better for some women than others. BV is the most common vaginal condition worldwide, affecting more than 25% … Read more

How Fred Hutch scientists tackle world’s top infectious killer, TB

But scientists are working toward better options. Shapiro was part of a committee that reviewed the evidence for a new TB tongue swab test, based on research from UW. Based on Shapiro and her colleagues’ recommendation, the WHO endorsed the approach earlier this month. The tongue swab test will help identify people with signs of … Read more

New method creates longer lasting CAR T cells for cancer therapy

A research team led by Albert Einstein College of Medicine scientists has developed a new strategy to engineer immune cells that dramatically prolongs their effectiveness after being infused into patients to fight cancer and HIV, addressing a major limitation of current treatments. Their findings, published today in Science Advances, describe a manufacturing approach that, compared … Read more

DNA origami vaccine platform shows promise against multiple infectious viruses

The COVID-19 pandemic brought messenger RNA (mRNA) vaccines to the forefront of global health care. After their clinical trial stages, the first COVID-19 mRNA vaccine was administered on 8 December 2020 and mathematical models suggest that mRNA vaccines prevented at least 14.4 million deaths from COVID-19 in the first year alone. Their extraordinary effectiveness in having … Read more

Spatial intelligence platform supports health policy decisions aimed at ending HIV

INCLIVA Healthcare Research Institute-University Clinical Hospital of Valencia, the Universitat Politècnica de València – through its VRAIN Institute, the Valencia Anti-AIDS Committee and the Centre for Epidemiological Studies on Sexually Transmitted Infections and AIDS in Catalonia (CEEISCAT) have joined forces to develop a spatial intelligence platform to support health policy decisions aimed at optimizing the … Read more

New HIV-seq tool advances understanding of persistent viral reservoirs

For people living with human immunodeficiency virus (HIV), life-saving antiretroviral therapy keeps their HIV-infected immune cells from making new copies of the virus, preventing illness and transmission. Historically, these infected cells have been known as the “latent” HIV reservoir-implying that the HIV within the infected cells is completely inactive. But notion that the entirety … Read more

Denmark first in EU to join Thailand and Malaysia in protecting newborns from HIV

Denmark has been certified by WHO for eliminating mother-to-child transmission of HIV and syphilis, joining countries such as Thailand and Malaysia in reaching the milestone. Photo: The Danish Ministry of the Interior and Health Until recently, mother-to-child transmission of HIV and syphilis remained a public health concern, with some babies infected at birth. Now Denmark … Read more

Genome sequencing data reveals new insights into Epstein-Barr virus immunity

The Epstein-Barr virus (EBV) can cause certain types of cancer or autoimmune diseases, but how the body controls this common viral infection is largely unknown. Researchers at the University Hospital Bonn (UKB) and the University of Bonn have now identified genetic and non-genetic factors that help the body fight EBV. To do this, they evaluated … Read more

Onset of “the munchies” after cannabis use could offer clues to help people with appetite loss

The urgent onset of “the munchies” after cannabis use isn’t imaginary – it’s a cognitive response that occurs regardless of sex, age, weight or recent food consumption and could offer clues to help people struggling with appetite loss. Those findings from a collaborative study, conducted by researchers at Washington State University and the University of … Read more

Novel antibody 007 targets the elusive HIV envelope epitope

HIV-1 can be neutralized by antibodies which bind to vulnerable structures on the virus surface. One such vulnerable site is the so-called V3 glycan site of the viral envelope protein. This target structure plays a central role in virus entry into human cells and has therefore long been an important focus for the development of … Read more